Integrated Bioanalytical Systems Research Group

Our interdisciplinary group specializes in the development of highly multiplex bioanalytical tools and methods, primarily in the context of lab-on-a-chip and microfluidics paradigms.

Our main research focus is on providing clinical medicine with analytical tools for diagnostics, theranostics, and biomedical research.

Main Research Areas 

Diagnostic systems: development of chip-oriented highly multiplex diagnostic tools that can simultaneously determine a set of parameters. Our methodological priorities are set on flow-through methods and on the image analysis of analytical matrices. Our chip engineering is based on lithography and 3D printing, while our data analysis uses algorithms and software developed internally, by our research group. A top-priority clinical task is the diagnosis of tick-borne diseases and COVID-like infections.

Development of tools that simultaneously analyze Genotype, Transcriptome, Phenotype, and Functional properties (a.k.a. GTPF analysis) of cells, mitochondria, exosomes, and other particles, containing polynucleotides in bulk. Integration of cytometry with methods allowing microdroplet coding of individual particle polynocleotides, such as DropSeq.

BioFabLab is an educational institution that produces commercial products, trains instrument-making professionals, commercializes inventions, and supports instrument-making import-substituting startups. For example, GTPF analysis’ «by-products» are Russian-made cytometers, FACS, and multiplex particles for microdroplet coding and analytical matrices.

Additional Research Areas:

Creation of hollow, magnetic, plasmonic, and fluorescent nanoparticles and their assemblies for drug delivery and theranostics; 
Electromagnetic manipulation of particles in liquid and gas media: electrostatic filters and classifier machine. Dielectrophoresis, magnetophoresis, capillary and free-flow electrophoresis. Optical manipulation. Electroosmotics.

Vacancies view the full list of vacancies here.






Research Team

		Dmitry S. Andreev Head of Research E-mail: a.g.bakanov@utmn.ru, aleksei.bakanov@gmail.com More Scientific interests Therapeutic treatment of infections, carcinogenesis, and aging through the analysis of cell and mitochondria heterogeneity. Multiplex analysis: flow analysis of particles, optical analysis of analytical matrices, microspectroscopy. Methods: capillary and “lab-on-a-chip” microfluidics, 3D-printing, lithography, electroosmotics, magnetophoresis Development of analytical and therapeutic equipment: hardware, software, techniques Engineering of micro- and nanoscale diagnostic, therapeutic, and theranostic particles and structures; methods for controlling such particles Education November 2007 - PhD in Bioanalytical Chemistry and Materials Science. Department of Chemistry, University of Minnesota, Minneapolis, USA. Dissertation: Development of Models and Analytical Approaches for Individual Mitochondria June 1996 - MSc in Chemistry. Iowa State University, Ames, USA June 1996 - Specialist in Chemistry. Higher Chemical College of the Russian Academy of Sciences, Moscow, Russia. Thesis: New bioanalytical applications of surface-enhanced fluorescence
		Aleksey G. Bakanov Research associate E-mail: a.g.bakanov@utmn.ru, aleksei.bakanov@gmail.com More Scientific interests Plasmonics and plasmonic nanostructures, SPASERs Quantum dots, metal nanoparticles Optical spectroscopy, SERS, FRET, Purcell effect, stimulated emission Education June 2011 - Specialist in Physics (Engineer). Faculty of Physics and Engineering of the Yanka Kupala State University of Grodno, Grodno, Republic of Belarus. Thesis: The influence of the CdSe/ZnS nanoparticles’ solubilization on their optical properties June 2013 – MSc (Optics of nanostructures). Faculty of Photonics and Optoinformatics, ITMO University, St. Petersburg, Russia. Thesis: Photophysical properties of CdSe/ZnS quantum dots in complexes with sulfophthalocyanine, contained in the «Photosense» drug December 2016 - Candidate of Physical and Mathematical Sciences (with a specialty in Optics). Faculty of Photonics and Optoinformatics, ITMO University, St. Petersburg, Russia. Dissertation: Optical properties of semiconductor quantum dots in the near field of plasmonic nanoparticles
		Shtepin Roman Pavlovich Engineer of 1 category E-mail: r.p.shtepin@utmn.ru More Scientific interests Radio electronics, microcontrollers, programming. Education 2005 - Physicist (Specialty) Tyumen State University
		Nasyrova Anna Engineer E-mail: nasyrovaanna51@gmail.com More Scientific interests Bioanalytical Instrumentation Optics Education 2020 - Master (Technical Physics). Physics and Technology Institute of Tyumen State University, (Tyumen, Russia). Thesis: Classification of low-permeability reservoirs by the degree of influence of nonlinear effects on filtration 2018 - Bachelor (Physics). Physics and Technology Institute of Tyumen State University (Tyumen, Russia). Thesis: Methods for the determination of the selective conductivity of semipermeable membranes
		Kharchenko Oleg Borisovich Research Engineer E-mail: obkharchenko@mail.ru More Scientific interests Electronics Electronic computing equipment The economic foundations of managing the supply of stocks of the enterprise Management (basics) Education 1986 - Design Engineer-Technologist, Kharkov Institute of Radio Electronics (Kharkov, Ukraine)
		Khudyshkin Vyacheslav Research Engineer E-mail: khudyshkin@yandex.ru More Scientific interests CAD, G-code, optical and extrusion 3D printing, micromilling, lithography, casting, etc. Development, assembly, setup and adaptation of laboratory instruments and equipment Chemistry of micro and nanoparticles, surface chemistry. Drip microfluidics, particle synthesis. Binding of biomolecules and paints Assembly, debugging of electronic circuits, including those using microcontrollers Education  June 2020 - Master's degree in Petroleum Chemistry and Environmental Safety. Institute of Chemistry, Tyumen State University (Tyumen, Russia) June 2018 - Bachelor, specialty "Academic Chemistry". Institute of Chemistry, Tyumen State University (Tyumen, Russia)
		Lebedev Egor Evgenievich Research laboratory assistant E-mail: mainsalta@gmail.com More Scientific interests Noncoding RNAs (miRNAs, lncRNAs) Embryology Bioinformatics Education November, 2020 - present - Postgraduate study (Entomology) at the Institute of Ecological and Agricultural Biology (X-BIO), Tyumen State University (Tyumen, Russia) July, 2020 - Master's degree (Biological systems: structure, functions, technologies). Far Eastern Federal University (Vladivostok, Russia) Thesis: Analysis of miRNA expression in the early embryonic development of the purple sea urchin  July 2018 - Bachelor (Molecular Cell Systems and Biotechnology). Far Eastern Federal University, Vladivostok, Russia Thesis: Transposons of the sea urchin Strongylocentrotus intermedius: in silico versus in vitro
		Shamsimukhametov Marat Educational project manager E-mail: m.shems@utmn.ru More Scientific interests International and Science Education Education 2017 - MA Science education, UCL Institute of Education (London, UK) Bachelor, Faculty of Biology and Soil Science, St. Petersburg State University (St. Petersburg, Russia)

Selected Publications

1. L. K. Kurbatov, S. P. Radko, S. V. Kravchenko, O. I. Kiseleva, N. D. Durmanov, and A. V. Lisitsa. Single Stage Purification of CRISPR/Cas13a Nuclease via Metal-Chelating Chromatography Following Heterologous Expression with the Preservation of Collateral Ribonuclease Activity. Applied Biochemistry and Microbiology, 2020, Vol. 56, No. 6, pp. 671–677
   
2. Andreyev, D.; Zybailov, B. Integration of flow cytometry and single cell sequencing. Trends Biotechnol., 2020. 38(2), p. 133-136